DNA helicases are motor proteins that translocate along nucleic acids to separate complementary strands, a step essential for replication, repair and recombination. By unwinding duplex DNA and ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

A newly mapped step in DNA replication suggests that strand separation begins at a precise junction between two helicase ...

DNA helicases are ATP-dependent motor proteins that unwind duplex DNA and remodel nucleic acid structures, underpinning virtually all facets of genome maintenance. In response to DNA lesions such as ...

Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...

Researchers at the MRC Laboratory of Medical Sciences, in partnership with other institutions, have pinpointed the exact ...

King Abdullah University of Science & Technology (KAUST)Mar 19 2025 Reviewed For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections - and, alas, extraordinarily difficult to target with drugs. Now, new ...

For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of efficacy ...

A research team led by Dr. Yuanliang Zhai from the School of Biological Sciences, The University of Hong Kong (HKU), and his collaborators from The Hong Kong University of Science and Technology ...

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections—and, alas, extraordinarily difficult to target with drugs. Now, new ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors This class of ...