Interleukin-6 (IL-6) is a multifaceted cytokine that serves as a critical mediator in immune regulation, inflammation and tissue regeneration. Its activity is mediated through several signalling ...

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. “Immunotherapy with checkpoint inhibitors is currently ...

Researchers have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6). Researchers at The University of Texas ...

CI denotes confidence interval, and SNP single-nucleotide polymorphism. Sequencing reads were aligned to the hg19 reference genome. A SIFT (sorting intolerant from tolerant) score of less than 0.05 ...

However, imbalances of IL-6 — too much or too little — can cause disease, even in the absence of infection. Excess IL-6 is central to the pathogenesis of inflammatory reactions like rheumatoid disease ...

Researchers at The University of Texas MD Anderson Cancer Center have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine ...

Interleukin-6 (IL-6) is a pleiotropic cytokine that may play a role in the regulation of various aspects of the immune response, inflammation, hematopoiesis, and bone metabolism. IL-6 acts by binding ...

In a recent study posted to Research Square*, researchers reported that plasma interleukin (IL)-6 levels in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 ...

Possible association of postmeiotic segregation increased 2 (PMS 2) gene deletion and myelodysplastic syndrome. This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I. This abstract does ...

We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the intensive ...